正丙醇_MSDS化学品安全技术说明书

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正丙醇-MSDS化学品安全技术说明书

发表时间：2011-10-31浏览次数：评论：分享：顶：踩：

品名

正丙醇; n-Propyl alcohol; Propanol-1; CAS:71-23-8

理化性质

为无色挥发性液体。分子式C3-H8-O。分子量60.11。沸点97.3 ℃。蒸气相对密度2.08。能与水、乙醇和乙醚混溶。

接触机会

在制作化妆品、油漆和制药工业以及使用其作天然胶、合成树脂、乙基纤维素及聚乙烯丁缩醛等的溶剂过程中接触本品。

国内主要生产厂商:北京化工厂、天津市化学试剂二厂、上海试剂一厂、西安化学试剂厂

侵入途径

可经消化道吸收。

毒理学简介

人（女性）LDLo: 5700 mg/kg。

大鼠经口LD50: 1870 mg/kg；吸入LCLo: 4000 ppm/4H。小鼠经口LD50: 6800 mg/kg；吸入LC50: 48 gm/m3。兔经皮LD50: 4060 mg/kg。

属低毒类。主要有刺激和麻醉作用,其毒性作用与乙醇相似。实验证明本品在狗体内的氧化和排泄比乙醇快得多。正丙醇的挥发度较低,不到乙醇的2/5,吸入其蒸气的机会较小。

IDLH: +800 ppm [R24]

临床表现

参见<异丙醇>

国外报道一例口服400ml而致死者,尸检发现脑水肿和肺水肿。

美国HSDB引用文献：

*n-Propyl alcohol can produce mild central nervous system depression. Other reported symptoms ... include dry cracking skin, drowsiness, headaches, ataxia, gastrointestinal pain, abdominal cramps, nausea, vomiting & diarrhea. [R35]

*THE ACTIVITY OF PARTIALLY PURIFIED HUMAN ERYTHROCYTE ACID PHOSPHATASE (EAPASE) WAS ENHANCED 3-FOLD BY N-PROPANOL. THE EXTENT OF HUMAN PROSTATIC ACID PHOSPHATASE (PAPASE) ACTIVATION BY N-PROPANOL WAS LOWER THAN THAT OF EAPASE. EAPASE & PAPASE ACTIVATION BY ALIPHATIC ALCOHOLS, INCLUDING N-PROPANOL, WAS NONCOMPETITIVE. [R36]

*Complete hemolysis or denaturation of human erythrocytes occurred in all aq propyl alc solutions after 45 min at 37 deg C. [R11]

*... MAY BE SLIGHTLY MORE TOXIC THAN ISOPROPYL ALCOHOL, BUT IT APPEARS TO INDUCE MANY OF THE SAME BIOLOGICAL EFFECTS. [R37,p. III-218]

*ETHANOL & CERTAIN SHORT CHAIN ARYL (BENZYL) & ALIPHATIC (PROPYL, BUTYL) ALCOHOLS PRODUCED UP TO 10 FOLD INCR IN CYCLIC AMP CONCN IN PURIFIED HUMAN PERIPHERAL BLOOD LYMPHOCYTES. ETHANOL CONCN AS LOW AS 80 MG/DL PRODUCED SIGNIFICANT ELEVATIONS IN LYMPHOCYTE CYCLIC AMP. [R38]

*A CASE IS REPORTED OF OCCUPATIONALLY ACQUIRED SENSITIVITY TO ISOPROPYL ALCOHOL IN WHICH, ON TESTING WITH GAS CHROMATOGRAPHICALLY PURIFIED MATERIAL, POSITIVE PATCH TEST REACTIONS WERE FOUND TO 1-PROPANOL, 1-BUTANOL, 2-PROPANOL, 2-BUTANOL. [R39]

*... /Isopropyl and n-propyl/ alcohols are about twice as toxic as ethanol; the fatal dose by ingestion is 250 ml. ... The principal manifestation of acute isopropyl or n-propyl poison is CNS depression. Symptoms and signs: (From inhalation, ingestion, or skin absorption) ... persistent nausea, vomiting, abdominal pain, hematemesis, refractory ... /CNS depression/, areflexia, depressed respirations, and oliguria followed by diuresis. ... Generalized tenderness, induration, and edema of muscles may occur. ... Prolonged contact with the skin can cause corrosion. [R40]

处理

对症治疗。参见<异丙醇>

标准

车间空气卫生标准：

美国MSHA STANDARD-air: TWA 200 ppm (490 mg/m3)

美国OSHA PEL(所有行业): 8H TWA 200 ppm (500 mg/m3)

澳大利亚: TWA 200 ppm (500 mg/m3), STEL 250 ppm, Skin JAN 1993;

比利时: TWA 200 ppm (492 mg/m3), STEL 250 ppm, Skin JAN 1993;

丹麦: TWA 200 ppm (500 mg/m3), Skin JAN 1993;

芬兰: TWA 200 ppm (500 mg/m3), STEL 250 ppm, Skin JAN 1993;

法国: TWA 200 ppm (500 mg/m3) JAN 1993;

匈牙利: TWA 100 mg/m3, STEL 200 mg/m3 JAN 1993;