品名

氰酸钾; Potassium cyanate; CAS：590-28-3

理化性质

白色结晶粉末。分子式KOCN。分子量81.11。相对密度2.056(20℃)。熔点700～900℃(分解)。溶于水; 极微溶于乙醇。加热分解,生成氰化物。

接触机会

用于有机合成,制造安眠药、麻醉药等,也可用作除草剂。

国内主要生产厂商:上海试剂二厂

侵入途径

可经消化道吸收。

毒理学简介

小鼠经口LD50: 841 mg/kg。

属低毒类。毒作用与氰酸钠相同。

给狗腹腔注射400mg/kg,出现呕吐、排便、排尿、流泪、流涎、呼吸加速、震颤、抽搐、甚至死亡。

临床表现

未见急性中毒报道。

美国HSDB引用文献：

*TWO PATIENTS DEVELOPED BILATERAL SUBCAPSULAR CATARACTS WHILE RECEIVING ORAL SODIUM CYANATE 30-35 MG/KG/DAY. IN ONE OF THE PATIENTS, LENS OPACITIES REGRESSED SPONTANEOUSLY AFTER CYANATE THERAPY WAS DISCONTINUED. /SODIUM CYANATE/ [R19]

*TWO PATIENTS WITH SICKLE-CELL DISEASE WHO WERE RECEIVING SODIUM CYANATE FOR 440 & 600 DAYS RESPECTIVELY IN DOSES OF UP TO 44 & 41 MG/KG/DAY HAD POLYNEUROPATHY CONFIRMED BY PHYSICAL EXAM, QUANTITATIVE SENSORY EVALUATION, NERVE CONDUCTION TEST, ELECTROMYOGRAPHY AND NEURAL BIOPSY. /SODIUM CYANATE/ [R20]

处理

对症处理。

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