品名

2,4,5-三氯酚; 2,4,5-Trichlorophenol; CAS：95-95-4

理化性质

无色针状或灰色片状晶体。分子式C6-H3-Cl3-O。分子量197.44。相对密度1.678(25/4℃)。凝固点57℃。沸点252℃。蒸气压0.13(1mmHg 72℃)。不溶于水; 溶于乙醇、乙醚、苯、四氯化碳。加热分解,生成氯化物。

接触机会

用于杀虫、杀菌剂。

侵入途径

经消化道吸收。

毒理学简介

大鼠经口LD50: 820 mg/kg。小鼠经口LD50: 600 mg/kg。

动物出现不安和呼吸加快,后出现无力、震颤、阵挛性抽搐、气急、昏迷,甚至死亡。震颤不强烈,但持续较久。

临床表现

未见急性中毒报道。中毒症状可参见 <苯酚> 。

美国HSDB转小组评审：

*Dermatoses, including photoallergic contact dermatitis, have been reported in man after exposure to 2,4,5-trichlorophenol ... these include papulofollicular lesions, comedomes, sebaceous cysts, and marked hyperkeratosis. [R30, 2615]

*TRICHLOROPHENOLS ... PRODUCE REDNESS & EDEMA ON SKIN CONTACT & ON PROLONGED EXPOSURE EVEN MILD TO MODERATE CHEMICAL BURNS OF SKIN OF MAN. IN EYE THEY INDUCE CONJUNCTIVAL IRRITATION & SOMETIMES CORNEAL INJURY & IRITIS. DUSTS ARE IRRITATING TO NOSE & PHARYNX. SYSTEMIC EFFECTS ... PRESUMABLY RESEMBLE ... PHENOL ... /TRICHLOROPHENOLS/ [R18,p. II-196]

*Where chemical contact has been gross, the worst known examples being during the clean-up following explosions during 2,4,5-trichlorophenol manufacture ... chloracne was generally severe, and many cases had some signs or symptoms or lab abnormalities indicating systemic toxicity. [R33]

*ALL /TRICHLOROPHENOLS/ ARE LESS TOXIC THAN SIMPLE PHENOL. ... SYSTEMIC EFFECTS ... PRESUMABLY RESEMBLE THOSE OF PHENOL POISONING. /TRICHLOROPHENOLS/ [R18,p. II-196]

处理

对症处理。

标准

危规：GB6.1 类61705。原铁规:有机有毒品,84152。

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