丙烯酸乙酯_MSDS化学品安全技术说明书

丙烯酸乙酯-MSDS化学品安全技术说明书

发表时间：2011-10-31浏览次数：评论：分享：顶：踩：

品名

丙烯酸乙酯; Ethyl acrylate; Ethyl 2-propenoate; Acrylic acid ethyl ester; CAS：140-88-5

理化性质

无色液体。易挥发。有辛辣刺激性气味。分子式C5-H8-O2。分子量100.11。相对密度0.9405(20/4℃)。凝固点<-72℃。沸点99.8℃。闪点15.56℃。自燃点382.78℃。蒸气密度3.45。蒸气压3.91kPa(29.3mmHg20℃)。蒸气与空气混合物爆炸下限1.8% 。20℃水中溶解度2g/100ml; 溶于乙醇、乙醚。静止时容易聚合; 热量、阳光、过氧化物将使聚合加速。水解缓慢。遇热、明火、氧化剂易燃。与氯磺酸发生剧烈反应。

接触机会

用作有机合中成间体及聚合物制造。为低沸点高蒸气压液体,故工作环境容易接触,浓度低于32.7mg/m^3即可嗅出。

国内主要生产厂商:北京东方化工厂

侵入途径

主要经呼吸道吸入。

毒理学简介

人吸入TCLo: 50 ppm。

大鼠经口LD50: 800 mg/kg; 吸入LC50: 1414 ppm/4H; 经皮LDLo: 1800 mg/kg。小鼠经口LD50: 1799 mg/kg; 吸入LC50: 16200 mg/m3; 经皮LD50: 2997 mg/kg。兔经皮LD50: 500 uL/kg。

不饱和酯毒性较相应饱和脂肪酸酯高约10倍。中毒动物除有刺激症状外,还有流涎等。对皮肤有轻微刺激,对眼有中度刺激。

临床表现

国内未见人中毒的报告。

美国HSDB引用文献：

*LACRIMATOR. ... LETHARGY & CONVULSIONS MAY OCCUR IF VAPORS OF THE MONOMER ARE INHALED IN HIGH CONCN. [R2, 862]

*... /ETHYL ACRYLATE HAS/ AN EXTREMELY IRRITATING ACTION ON THE ENTIRE /RESP/ TRACT. RESP ... RAPID, THE LIPS BLUE, & CONVULSIVE MOVEMENTS ... DEATH /SRP: CAN OCCUR/ FOLLOWING PULMONARY EDEMA. ... CAUSES SERIOUS BURNS OF THE CORNEA & MAKES IT OPAQUE. [R48]

*ETHYL ACRYLATE TESTED @ 4% IN PETROLEUM PRODUCED NO IRRITATION AFTER 48-HR CLOSED PATCH TEST ON HUMAN SUBJECTS. A MAXIMIZATION TEST WAS CARRIED OUT ON 24 VOLUNTEERS. MATERIAL WAS TESTED @ CONCN OF 4% IN PETROLEUM & PRODUCED SENSITIZATION REACTIONS IN 10 OF THE 24. [R12]

*Ethyl acrylate is irritating to the ... mucous membranes of the gastrointestinal tract and respiratory system. ... Prolonged exposure to 205-308 mg/cu m (50-75 ppm) ethyl acrylate produced drowsiness, headache and nausea. 14 of 33 workers exposed over an average period of five years to 4-58 mg/cu m ethyl acrylate (and 50 mg/cu m butyl acrylate) complained of autonomic and neurotic symptoms, eletroencephalographic examination showed no organic dysfunction. [R49]

*ONE CASE REPORT INDICATED THAT A WORKER EXPOSED TO DUST OF A POLYMER OF ETHYL ACRYLATE WAS HOSPITALIZED FOR THE INVESTIGATION OF A RESP COUGH; ITCHING OF SKIN OF THE FACE & EARS ALSO OCCURRED. /POLYMER/ [R50]

*WHEN COMPARING STRAIGHT WITH BRANCHED CHAIN ACRYLATES, ETHYL ACRYLATE BY ORAL ROUTE MAY BE ONLY HALF AS TOXIC AS METHYL ACRYLATE, BUT EIGHT TIMES AS TOXIC AS METHYL METHACRYLATE, & 13 TIMES AS TOXIC AS ETHYL METHACRYLATE. [R36, 2292]

*SENSITIZATION OF WORKERS, PRESUMABLY BY SKIN CONTACT WITH THE LIQ, HAS BEEN REPORTED BY TWO MANUFACTURERS ... . [R51]

处理

对症处理。

标准

车间空气卫生标准：

美国ACGIH TLV-STEL 61 mg/m3 (15 ppm)

美国ACGIH TLV-TWA 20 mg/m3 (5 ppm)

美国MSHA STANDARD-air: TWA 25 ppm (100 mg/m3) (皮肤)

美国OSHA PEL(所有行业): 8H TWA 25 ppm (100 mg/m3) (皮肤)

澳大利亚: TWA 5 ppm (20 mg/m3)

比利时: TWA 5 ppm (20 mg/m3), STEL 25 ppm (100 mg/m3)

丹麦: TWA 5 ppm (20 mg/m3), 皮肤, 致癌物