乙二醇单乙基醚_MSDS化学品安全技术说明书

乙二醇单乙基醚-MSDS化学品安全技术说明书

发表时间：2011-10-31浏览次数：评论：分享：顶：踩：

品名

乙二醇单乙基醚; 2-乙氧基乙醇; 溶纤剂; Ethylene glycol monoethylether; 2-Ethoxyethanol; Oxitol; Dowanol EE; CAS：110-80-5

理化性质

无色液体,几乎无味。分子式C4-H10-O2。分子量90.12。相对密度0.931(20/20℃)。凝固点 -70℃。沸点135℃。闪点44.44℃(闭杯)。自燃点235℃。蒸气密度3.10。蒸气压0.51kPa (3.8mmHg 20℃)。蒸气与空气混合物可燃限1.7～15.6%(93℃)。与水、乙醇、乙醚、丙酮混溶。遇热、明火易燃烧、爆炸。能与氧化物反应。

接触机会

作为多种树脂、喷漆、颜料、清洁剂和液体肥皂的溶剂。也作为稀释剂和某些化学中间产物而广泛使用。

国内主要生产厂商:上海试剂三厂

侵入途径

消化道、呼吸道和皮肤。

毒理学简介

大鼠经口LD50: 2125 mg/kg; 吸入LC50: 2000 ppm/7H。小鼠经口LD50: 2451 mg/kg; 吸入LC50: 1820 ppm/7H。兔经皮LD50: 3300 mg/kg。

属低毒类。重复经口,每天以0.1ml/kg喂兔,第7天出现暂时性蛋白尿; 0.25ml/kg,第7天出现蛋白尿和血尿。当增加到1ml/kg,动物于第8天因肾损害而死亡。皮肤接触未见刺激性但中毒剂量可通过皮肤吸收。小鼠吸入死亡是由于肺和肾损害。

人口服(妇女)最低中毒剂量为600mg/kg,吸入最低中毒浓度为195 ppm/8h。

IDLH: *500 ppm [R13]

临床表现

使用本品除引起粘膜刺激和头痛外,未见急性中毒病例。

美国HSDB引用文献：

*THE EFFECTS /OF ALKYL DERIV OF ETHYLENE GLYCOL/ ... UPON THE CNS INCLUDE HEADACHE, DROWSINESS, WEAKNESS, SLURRED SPEECH, RECRUDESCENT STUTTERING, STAGGERING GAIT, TREMOR, AND BLURRED VISION. CHANGES OF PERSONALITY ARE OFTEN NOTED ... THESE CHANGES ARE SUCH THAT THE PATIENT, IN THE ABSENCE OF AN ACCURATE OCCUPATIONAL HISTORY, MAY BE TREATED FOR SCHIZOPHRENIA OR NARCOLEPSY. IN ACUTE POISONING WITH THE ETHYLENE GLYCOL MONOALKYL ETHERS, THERE IS ... RENAL INJURY: ALBUMINURIA & HEMATURIA. /ETHYLENE GLYCOL MONOALKYL ETHERS/ [R25]

*IN ... TWO CASES, /IN/ WORKMEN WHO HAD BEEN EMPLOYED FOR 13 YR IN LACQUER AND PIGMENT FACTORIES ... INJURIOUS EFFECT /HAS/ BEEN REPORTED. THIS CONSISTED IN ONE OF A SLIGHT YELLOWISH DISCOLORATION OF ... /SCLERA/ AND IN THE OTHER A TRACE OF ALBUMIN IN THE URINE AND A SLIGHTLY INCREASED LEVEL OF UROBILIN IN BLOOD ... [R17, 604]

*CENTRAL NERVOUS DEPRESSION AS WITH ETHYLENE GLYCOL, BUT THE ETHER DERIVATIVES PRODUCE MORE MARKED KIDNEY INJURY AND HEMATURIA (APPARENTLY WITHOUT OXALIC ACID FORMATION OR CRYSTALLURIA). [R26,p. II-182]

*Ethylene glycol monomethyl ether and ethylene glycol monoethyl ether have recently been shown to have the potential to induce reproductive toxicity. [R27, 705]

处理

对症治疗。

标准

车间空气卫生标准：

美国ACGIH TLV-TWA 18 mg/m3 (5 ppm) (皮肤)

美国MSHA STANDARD-air: TWA 100 ppm (370 mg/m3) (皮肤)

美国OSHA PEL(所有行业): 8H TWA 200 ppm (740 mg/m3) (皮肤)

澳大利亚: TWA 5 ppm (19 mg/m3), 皮肤

比利时: TWA 5 ppm (18 mg/m3), 皮肤

丹麦: TWA 5 ppm (18.5 mg/m3), 皮肤

芬兰: TWA 50 ppm (185 mg/m3), STEL 100 ppm (370 mg/m3), 皮肤

法国: TWA 5 ppm (19 mg/m3), 皮肤