二乙胺_MSDS化学品安全技术说明书

二乙胺-MSDS化学品安全技术说明书

发表时间：2011-10-31浏览次数：评论：分享：顶：踩：

品名

二乙胺; N-乙基乙胺; Diethylamine; N-Ethylethanamne; CAS：109-89-7

理化性质

易挥发的无色液体。有氨味。分子式C4-H11-N。化学式(C2H5)2NH。分子量73.14。相对密度0.7108(20/20℃)。凝固点-38.9℃。沸点55.5 ℃。闪点<-6.67℃。自燃点312.22℃。蒸气密度2.53。蒸气压53.32kPa(400mmHg 38℃)。蒸气与空气混合物爆炸限1.8～10.1% 。与水、乙醇混溶。水溶液呈碱性。有腐蚀性,能蚀刻玻璃。遇热、明火、强氧化剂易燃烧、爆炸。加热分解,生成氮氧化物。不能与硝酸纤维素共存。

接触机会

用于制药、染料、橡胶硫化促进剂、乳化剂、固化剂和杀菌剂等。用作金属的酸性腐蚀阻化剂。

国内主要生产厂商:株州选矿药剂厂、重庆西南制药二厂、上海大丰化工厂、辽宁省开源县化肥厂、南京制药厂、张家口市宣化农药厂

侵入途径

可经呼吸道、消化道和皮肤吸收。

毒理学简介

大鼠经口LD50: 540 mg/kg; 吸入LC50: 4000 ppm/4H。小鼠经口LD50: 500 mg/kg; 吸入LCLo: 3 gm/m3/2H。兔经皮LD50: 820 uL/kg。

本品属低毒类。侵入人体后大部分经尿排出体外,口服二乙胺盐酸盐5g,约86%经尿排泄。

动物中毒表现为先兴奋后抑制,并伴严重的刺激症状。染毒期间死亡的小鼠,常见肺充血、水肿、脑、肝、脾充血; 染毒后数天死亡的小鼠,见肺充血、水肿,支气管上皮细胞肿大,肝细胞弥漫性脂肪变性和小灶性坏死,脑充血,有的软脑膜水肿。大鼠暴露在500～1000mg/m^3浓度1小时,严重影响条件和非条件反射。将鼠尾浸入二乙胺液中2小时,次日2只小鼠均死亡。

本品对皮肤和眼具刺激作用。

IDLH: +200 ppm [R17]

临床表现

本品污染皮肤,可致II～III度化学灼伤。本品溅入眼内,可致角膜灼伤。

美国HSDB引用文献：

*Edema of the epithelium of the cornea, generally without pain, has been produced by amine /incl diethylamine/ vapors, causing colored halos to be seen around lights ... . [R29, 75]

*There have been reports of temporary blue hazy vision from subtle disturbance of the corneal epithelium in people exposed to ethylamines. ... Diethylamine has been identified as having this effect, but it is not clear whether ethylamine and triethylamine also have have this action. /Ethylamines/ [R29, 413]

*... Vision has become misty and halos have appeared several hr after workmen have been exposed to the vapors of ... amines /incl diethylamine, dimethylamine, ethylenediamine/ at concn too low to cause discomfort or disability during several hr of exposure. ... The edema of the corneal epithelium, which is principally responsible for the disturbance of vision, clears spontaneously by the next day, but after exceptionally intense exposures the edema and blurring have taken several days to clear and have been accompanied by photophobia and discomfort from roughness of the corneal surface. [R29, 76]

*... Strong local irritation ... [R14]

*The formation of carcinogenic nitrosamines can ... occur in the stomach when secondary amines, such as those present in fish, vegetables, and fruit juices, come in contact with nitrite, which is often used as a food additive in meats and smoked fish. /Secondary amines/ [R30]

处理

去污染,对症治疗。

标准

车间空气卫生标准：

美国ACGIH TLV-STEL 45 mg/m3 (15 ppm) (皮肤)

美国ACGIH TLV-TWA 15 mg/m3 (5 ppm)

美国MSHA STANDARD-air: TWA 25 ppm (75 mg/m3)

美国OSHA PEL(所有行业): 8H TWA 25 ppm (75 mg/m3)

澳大利亚: TWA 10 ppm (30 mg/m3), STEL 25 ppm (75 mg/m3)

奥地利: TWA 10 ppm (30 mg/m3)

比利时: TWA 10 ppm (30 mg/m3), STEL 25 ppm (75 mg/m3)

丹麦: TWA 10 ppm (30 mg/m3)